Implant success is contingent on the osseointegration process. Successful osseointegration of bone growth around an implant is dependent on substrate properties, including surface morphology, chemical composition, and surface energy.
Dentalis’s dental implant innovation was developed and tested in three essential research levels, and has the advantages to enhance immediate and successful osseointegration.
Dentalis’s implants encompass unique and advanced implant macrotopography.
Dentalis’s implant’s chemical composition is well characterized.
Dentalis’s implant surface was produced with specific micron-scale surface structures.
Dentalis’s implants were examined and established under in-vitro cell culture studies and in-vivo conditions. In-vitro findings established that these specific surface structures enhanced osteoblast attachment, proliferation, differentiation, and mineralization, while in-vivo studies confirmed the osteogenic effect of microstructures on Ti substrates. These surfaces vastly improved bone-to-implant contact (BIC) in comparison to smooth-surfaced implants, which is correlated with improvements in removal torque strength.
These observations suggest that Dentalis implants, inspired by bone biology, will improve your clinical performance and outcome.
Dentalis Surface roughness is achieved by grit-blasting with a unique combination of
HA particles (soluble) and different sizes of grains. This process creates optimal structural roughness on the surface and enables the incorporation of biocompatible particles, such as HA and TCP.
Determination of Ra values
Roughness was measured with an average roughness (Ra), the most commonly used
parameter for describing roughness, was calculated in microns. The rough surfaces
produced by grit-blasting had irregular geometries with Ra value of 3.0 μm, which is
considered optimal for the osseointegration process.
Biological Response – In Vitro Study
Dentalis’s implant surface is the result of comprehensive scientific research examining the surface characteristics of dental implants, in order to optimize the biological response. Research on Dentalis’ surface examines the following properties:
Alkaline phosphatase as an early marker of differentiation – a compound that reaches its highest concentrationss as mineralization is initiated. Osteocalcin is a late marker of differentiation, and increases as mineral is deposited. Prostaglandin E2 is required for osteoblast activity, and prostaglandins mediate cell response to surface structure.
Most of the transforming growth factor beta-1 secreted by MG63 cells on microstructured
Ti surfaces is stored in latent form, and the amount is sensitive to surface structure.
These growth factors stimulate matrix synthesis and differentiation of osteoblasts and also
In-vivo: Studies have confirmed the osteogenic effect of microstructures on Ti substrates. These
surfaces improved bone-to-implant contact (BIC) in comparison to smooth-surfaced
implants, and this was correlated with 344% more stability and improved removal torque strength.
These observations suggest that Dentalis implants, inspired by bone biology, will improve
your clinical performance and outcome.